ICDwise
C49 ⚠ Non-billable

Malignant neoplasm of other connective and soft tissue

ICD-10-CM · FY2026 · Neoplasms

Code
C49
System
ICD-10-CM
Billable
No — use specific code
Effective
FY2026
Chapter
Neoplasms
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.

Official coding notes

From CMS's ICD-10-CM Tabular List.

Includes
  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat
  • malignant neoplasm of ligament, except uterine
  • malignant neoplasm of lymphatic vessel
  • malignant neoplasm of muscle
  • malignant neoplasm of synovia
  • malignant neoplasm of tendon (sheath)
Excludes1 — never code together
  • malignant neoplasm of cartilage (of):
  • articular (C40-C41)
  • larynx (C32.3)
  • nose (C30.0)
  • malignant neoplasm of connective tissue of breast (C50.-)
Excludes2 — not included here, but may code together
  • Kaposi's sarcoma of soft tissue (C46.1)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
  • malignant neoplasm of peritoneum (C48.2)
  • malignant neoplasm of retroperitoneum (C48.0)
  • malignant neoplasm of uterine ligament (C57.3)
  • mesothelioma (C45.-)

Frequently asked questions

What is ICD-10 code C49?
ICD-10-CM code C49 represents Malignant neoplasm of other connective and soft tissue. It is a non-billable header code requiring a more specific subcategory in the Neoplasms chapter, effective October 1, 2025 – September 30, 2026.
Is C49 billable?
No. C49 is a non-billable header. Select a more specific subcategory for claims submission.
What chapter is C49 in?
C49 belongs to the Neoplasms chapter (C00–D49) of ICD-10-CM.

Related codes in the C49 category

C49.0 Malignant neoplasm of connective and soft tissue of head, face and neck Billable C49.1 Malignant neoplasm of connective and soft tissue of upper limb, including shoulder Non-billable C49.2 Malignant neoplasm of connective and soft tissue of lower limb, including hip Non-billable C49.3 Malignant neoplasm of connective and soft tissue of thorax Billable C49.4 Malignant neoplasm of connective and soft tissue of abdomen Billable C49.5 Malignant neoplasm of connective and soft tissue of pelvis Billable C49.6 Malignant neoplasm of connective and soft tissue of trunk, unspecified Billable C49.8 Malignant neoplasm of overlapping sites of connective and soft tissue Billable

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