E05.21
✓ Billable
Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm
ICD-10-CM · FY2026 · Endocrine, Nutritional and Metabolic Diseases
Code
E05.21
System
ICD-10-CM
Billable
Yes — valid for submission
Effective
FY2026
Chapter
Endocrine, Nutritional and Metabolic Diseases
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Frequently asked questions
What is ICD-10 code E05.21?
ICD-10-CM code E05.21 represents Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm. It is a billable diagnosis code in the Endocrine, Nutritional and Metabolic Diseases chapter, effective October 1, 2025 – September 30, 2026.
Is E05.21 billable?
Yes. E05.21 is a valid billable ICD-10-CM code for insurance claims and clinical documentation.
What chapter is E05.21 in?
E05.21 belongs to the Endocrine, Nutritional and Metabolic Diseases chapter (E00–E89) of ICD-10-CM.
Related codes in the E05 category
E05
Thyrotoxicosis [hyperthyroidism]
Non-billable
E05.0
Thyrotoxicosis with diffuse goiter
Non-billable
E05.1
Thyrotoxicosis with toxic single thyroid nodule
Non-billable
E05.2
Thyrotoxicosis with toxic multinodular goiter
Non-billable
E05.3
Thyrotoxicosis from ectopic thyroid tissue
Non-billable
E05.4
Thyrotoxicosis factitia
Non-billable
E05.8
Other thyrotoxicosis
Non-billable
E05.9
Thyrotoxicosis, unspecified
Non-billable
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