E21
⚠ Non-billable
Hyperparathyroidism and other disorders of parathyroid gland
ICD-10-CM · FY2026 · Endocrine, Nutritional and Metabolic Diseases
Code
E21
System
ICD-10-CM
Billable
No — use specific code
Effective
FY2026
Chapter
Endocrine, Nutritional and Metabolic Diseases
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Official coding notes
From CMS's ICD-10-CM Tabular List.
Excludes1 — never code together
- adult osteomalacia (M83.-)
- ectopic hyperparathyroidism (E34.2)
- hungry bone syndrome (E83.81)
- infantile and juvenile osteomalacia (E55.0)
Excludes2 — not included here, but may code together
- familial hypocalciuric hypercalcemia (E83.52)
Frequently asked questions
What is ICD-10 code E21?
ICD-10-CM code E21 represents Hyperparathyroidism and other disorders of parathyroid gland. It is a non-billable header code requiring a more specific subcategory in the Endocrine, Nutritional and Metabolic Diseases chapter, effective October 1, 2025 – September 30, 2026.
Is E21 billable?
No. E21 is a non-billable header. Select a more specific subcategory for claims submission.
What chapter is E21 in?
E21 belongs to the Endocrine, Nutritional and Metabolic Diseases chapter (E00–E89) of ICD-10-CM.
Related codes in the E21 category
E21.0
Primary hyperparathyroidism
Billable
E21.1
Secondary hyperparathyroidism, not elsewhere classified
Billable
E21.2
Other hyperparathyroidism
Billable
E21.3
Hyperparathyroidism, unspecified
Billable
E21.4
Other specified disorders of parathyroid gland
Billable
E21.5
Disorder of parathyroid gland, unspecified
Billable
Search all 98,186 ICD-10-CM codes instantly
Search ICDwise →