E88.81
⚠ Non-billable
Metabolic syndrome and other insulin resistance
ICD-10-CM · FY2026 · Endocrine, Nutritional and Metabolic Diseases
Code
E88.81
System
ICD-10-CM
Billable
No — use specific code
Effective
FY2026
Chapter
Endocrine, Nutritional and Metabolic Diseases
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Frequently asked questions
What is ICD-10 code E88.81?
ICD-10-CM code E88.81 represents Metabolic syndrome and other insulin resistance. It is a non-billable header code requiring a more specific subcategory in the Endocrine, Nutritional and Metabolic Diseases chapter, effective October 1, 2025 – September 30, 2026.
Is E88.81 billable?
No. E88.81 is a non-billable header. Select a more specific subcategory for claims submission.
What chapter is E88.81 in?
E88.81 belongs to the Endocrine, Nutritional and Metabolic Diseases chapter (E00–E89) of ICD-10-CM.
Related codes in the E88 category
E88
Other and unspecified metabolic disorders
Non-billable
E88.0
Disorders of plasma-protein metabolism, not elsewhere classified
Non-billable
E88.1
Lipodystrophy, not elsewhere classified
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E88.2
Lipomatosis, not elsewhere classified
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E88.3
Tumor lysis syndrome
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E88.4
Mitochondrial metabolism disorders
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E88.8
Other specified metabolic disorders
Non-billable
E88.9
Metabolic disorder, unspecified
Billable
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