O99.321
✓ Billable
Drug use complicating pregnancy, first trimester
ICD-10-CM · FY2026 · Pregnancy, Childbirth and the Puerperium
Code
O99.321
System
ICD-10-CM
Billable
Yes — valid for submission
Effective
FY2026
Chapter
Pregnancy, Childbirth and the Puerperium
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Frequently asked questions
What is ICD-10 code O99.321?
ICD-10-CM code O99.321 represents Drug use complicating pregnancy, first trimester. It is a billable diagnosis code in the Pregnancy, Childbirth and the Puerperium chapter, effective October 1, 2025 – September 30, 2026.
Is O99.321 billable?
Yes. O99.321 is a valid billable ICD-10-CM code for insurance claims and clinical documentation.
What chapter is O99.321 in?
O99.321 belongs to the Pregnancy, Childbirth and the Puerperium chapter (O00–O9A) of ICD-10-CM.
Related codes in the O99 category
O99
Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
Non-billable
O99.0
Anemia complicating pregnancy, childbirth and the puerperium
Non-billable
O99.1
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
Non-billable
O99.2
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
Non-billable
O99.3
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
Non-billable
O99.4
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
Non-billable
O99.5
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
Non-billable
O99.6
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
Non-billable
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