R65
⚠ Non-billable
Symptoms and signs specifically associated with systemic inflammation and infection
ICD-10-CM · FY2026 · Symptoms, Signs and Abnormal Clinical and Laboratory Findings
Code
R65
System
ICD-10-CM
Billable
No — use specific code
Effective
FY2026
Chapter
Symptoms, Signs and Abnormal Clinical and Laboratory Findings
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Frequently asked questions
What is ICD-10 code R65?
ICD-10-CM code R65 represents Symptoms and signs specifically associated with systemic inflammation and infection. It is a non-billable header code requiring a more specific subcategory in the Symptoms, Signs and Abnormal Clinical and Laboratory Findings chapter, effective October 1, 2025 – September 30, 2026.
Is R65 billable?
No. R65 is a non-billable header. Select a more specific subcategory for claims submission.
What chapter is R65 in?
R65 belongs to the Symptoms, Signs and Abnormal Clinical and Laboratory Findings chapter (R00–R99) of ICD-10-CM.
Related codes in the R65 category
R65.1
Systemic inflammatory response syndrome (SIRS) of non-infectious origin
Non-billable
R65.2
Severe sepsis
Non-billable
R65.10
Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
Billable
R65.11
Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
Billable
R65.20
Severe sepsis without septic shock
Billable
R65.21
Severe sepsis with septic shock
Billable
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