R97.21
✓ Billable
Rising PSA following treatment for malignant neoplasm of prostate
ICD-10-CM · FY2026 · Symptoms, Signs and Abnormal Clinical and Laboratory Findings
Code
R97.21
System
ICD-10-CM
Billable
Yes — valid for submission
Effective
FY2026
Chapter
Symptoms, Signs and Abnormal Clinical and Laboratory Findings
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Frequently asked questions
What is ICD-10 code R97.21?
ICD-10-CM code R97.21 represents Rising PSA following treatment for malignant neoplasm of prostate. It is a billable diagnosis code in the Symptoms, Signs and Abnormal Clinical and Laboratory Findings chapter, effective October 1, 2025 – September 30, 2026.
Is R97.21 billable?
Yes. R97.21 is a valid billable ICD-10-CM code for insurance claims and clinical documentation.
What chapter is R97.21 in?
R97.21 belongs to the Symptoms, Signs and Abnormal Clinical and Laboratory Findings chapter (R00–R99) of ICD-10-CM.
Related codes in the R97 category
R97
Abnormal tumor markers
Non-billable
R97.0
Elevated carcinoembryonic antigen [CEA]
Billable
R97.1
Elevated cancer antigen 125 [CA 125]
Billable
R97.2
Elevated prostate specific antigen [PSA]
Non-billable
R97.8
Other abnormal tumor markers
Billable
R97.20
Elevated prostate specific antigen [PSA]
Billable
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