Z21
✓ Billable
Asymptomatic human immunodeficiency virus [HIV] infection status
ICD-10-CM · FY2026 · Factors Influencing Health Status
Code
Z21
System
ICD-10-CM
Billable
Yes — valid for submission
Effective
FY2026
Chapter
Factors Influencing Health Status
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Official coding notes
From CMS's ICD-10-CM Tabular List.
Also known as
- HIV positive NOS
Excludes1 — never code together
- acquired immunodeficiency syndrome (B20)
- contact with human immunodeficiency virus [HIV] (Z20.6)
- exposure to human immunodeficiency virus [HIV] (Z20.6)
- human immunodeficiency virus [HIV] disease (B20)
- inconclusive laboratory evidence of human immunodeficiency virus [HIV] (R75)
Code first
- Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
Frequently asked questions
What is ICD-10 code Z21?
ICD-10-CM code Z21 represents Asymptomatic human immunodeficiency virus [HIV] infection status. It is a billable diagnosis code in the Factors Influencing Health Status chapter, effective October 1, 2025 – September 30, 2026.
Is Z21 billable?
Yes. Z21 is a valid billable ICD-10-CM code for insurance claims and clinical documentation.
What chapter is Z21 in?
Z21 belongs to the Factors Influencing Health Status chapter (Z00–Z99) of ICD-10-CM.
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