D81
⚠ Non-billable
Combined immunodeficiencies
ICD-10-CM · FY2026 · Diseases of the Blood and Blood-Forming Organs
Code
D81
System
ICD-10-CM
Billable
No — use specific code
Effective
FY2026
Chapter
Diseases of the Blood and Blood-Forming Organs
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Frequently asked questions
What is ICD-10 code D81?
ICD-10-CM code D81 represents Combined immunodeficiencies. It is a non-billable header code requiring a more specific subcategory in the Diseases of the Blood and Blood-Forming Organs chapter, effective October 1, 2025 – September 30, 2026.
Is D81 billable?
No. D81 is a non-billable header. Select a more specific subcategory for claims submission.
What chapter is D81 in?
D81 belongs to the Diseases of the Blood and Blood-Forming Organs chapter (D50–D89) of ICD-10-CM.
Related codes in the D81 category
D81.0
Severe combined immunodeficiency [SCID] with reticular dysgenesis
Billable
D81.1
Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
Billable
D81.2
Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
Billable
D81.3
Adenosine deaminase [ADA] deficiency
Non-billable
D81.4
Nezelof's syndrome
Billable
D81.5
Purine nucleoside phosphorylase [PNP] deficiency
Billable
D81.6
Major histocompatibility complex class I deficiency
Billable
D81.7
Major histocompatibility complex class II deficiency
Billable
Search all 98,186 ICD-10-CM codes instantly
Search ICDwise →