D81.5
✓ Billable
Purine nucleoside phosphorylase [PNP] deficiency
ICD-10-CM · FY2026 · Diseases of the Blood and Blood-Forming Organs
Code
D81.5
System
ICD-10-CM
Billable
Yes — valid for submission
Effective
FY2026
Chapter
Diseases of the Blood and Blood-Forming Organs
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Frequently asked questions
What is ICD-10 code D81.5?
ICD-10-CM code D81.5 represents Purine nucleoside phosphorylase [PNP] deficiency. It is a billable diagnosis code in the Diseases of the Blood and Blood-Forming Organs chapter, effective October 1, 2025 – September 30, 2026.
Is D81.5 billable?
Yes. D81.5 is a valid billable ICD-10-CM code for insurance claims and clinical documentation.
What chapter is D81.5 in?
D81.5 belongs to the Diseases of the Blood and Blood-Forming Organs chapter (D50–D89) of ICD-10-CM.
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