D81.6
✓ Billable
Major histocompatibility complex class I deficiency
ICD-10-CM · FY2026 · Diseases of the Blood and Blood-Forming Organs
Code
D81.6
System
ICD-10-CM
Billable
Yes — valid for submission
Effective
FY2026
Chapter
Diseases of the Blood and Blood-Forming Organs
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Frequently asked questions
What is ICD-10 code D81.6?
ICD-10-CM code D81.6 represents Major histocompatibility complex class I deficiency. It is a billable diagnosis code in the Diseases of the Blood and Blood-Forming Organs chapter, effective October 1, 2025 – September 30, 2026.
Is D81.6 billable?
Yes. D81.6 is a valid billable ICD-10-CM code for insurance claims and clinical documentation.
What chapter is D81.6 in?
D81.6 belongs to the Diseases of the Blood and Blood-Forming Organs chapter (D50–D89) of ICD-10-CM.
Related codes in the D81 category
D81
Combined immunodeficiencies
Non-billable
D81.0
Severe combined immunodeficiency [SCID] with reticular dysgenesis
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D81.1
Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
Billable
D81.2
Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
Billable
D81.3
Adenosine deaminase [ADA] deficiency
Non-billable
D81.4
Nezelof's syndrome
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D81.5
Purine nucleoside phosphorylase [PNP] deficiency
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D81.7
Major histocompatibility complex class II deficiency
Billable
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