Z16
⚠ Non-billable
Resistance to antimicrobial drugs
ICD-10-CM · FY2026 · Factors Influencing Health Status
Code
Z16
System
ICD-10-CM
Billable
No — use specific code
Effective
FY2026
Chapter
Factors Influencing Health Status
Source
CMS / CDC NCHS
⚠ Verify before billing. Confirm against the current CMS/NCHS ICD-10-CM files and your payer's rules before claims submission.
Official coding notes
From CMS's ICD-10-CM Tabular List.
Excludes1 — never code together
- Methicillin resistant Staphylococcus aureus infection (A49.02)
- Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
- Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)
Code first
- the infection
Note
- The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
Frequently asked questions
What is ICD-10 code Z16?
ICD-10-CM code Z16 represents Resistance to antimicrobial drugs. It is a non-billable header code requiring a more specific subcategory in the Factors Influencing Health Status chapter, effective October 1, 2025 – September 30, 2026.
Is Z16 billable?
No. Z16 is a non-billable header. Select a more specific subcategory for claims submission.
What chapter is Z16 in?
Z16 belongs to the Factors Influencing Health Status chapter (Z00–Z99) of ICD-10-CM.
Related codes in the Z16 category
Z16.1
Resistance to beta lactam antibiotics
Non-billable
Z16.2
Resistance to other antibiotics
Non-billable
Z16.3
Resistance to other antimicrobial drugs
Non-billable
Z16.10
Resistance to unspecified beta lactam antibiotics
Billable
Z16.11
Resistance to penicillins
Billable
Z16.12
Extended spectrum beta lactamase (ESBL) resistance
Billable
Z16.13
Resistance to carbapenem
Billable
Z16.19
Resistance to other specified beta lactam antibiotics
Billable
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